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Os Mutantes ("The Mutants") are an influential Brazilian psychedelic rock band that were linked with the Tropicália movement of the late 1960s.

When Os Mutantes was formed, it combined influences from psychedelic acts from the English-speaking world like The Beatles, Jimi Hendrix, and Sly & the Family Stone with bossa nova, tropicália, samba and the cultural legacy of the Brazilian art vanguards from the modernist movement.

One of the most well-known and influential rock bands in Brazil, Os Mutantes are cited as a major influence to many contemporary underground or independent bands in the United States and Europe. Beck paid tribute to the group with his single "Tropicália" from the album Mutations.

The Bees (UK band) covered "A Minha Menina" on their first album, Sunshine Hit Me. Red Hot Chili Peppers bass player Flea has stated on his Twitter account that he is a fan. Kevin Barnes of Of Montreal cites Os Mutantes as an important influence. Talking Heads frontman David Byrne has worked to publish and promote the group's music through his Luaka Bop label